{"id":3697,"date":"2020-06-06T14:59:28","date_gmt":"2020-06-06T12:59:28","guid":{"rendered":"https:\/\/elisabettalungo.it\/home\/?p=3697"},"modified":"2020-06-06T15:30:11","modified_gmt":"2020-06-06T13:30:11","slug":"follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle","status":"publish","type":"post","link":"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/","title":{"rendered":"Follistatina-288-Fc"},"content":{"rendered":"<p>La follistatina \u00e8 una glicoproteina endogena che promuove la crescita e la riparazione del muscolo scheletrico sequestrando i ligandi inibitori della superfamiglia del TGF-\u03b2 e pu\u00f2 quindi avere un potenziale terapeutico per le malattie neuromuscolari. Nell&#8217;articolo seguente si \u00e8 cercato di determinare l&#8217;idoneit\u00e0 di una proteina di nuova concezione (FST288-Fc) per promuovere la crescita localizzata, piuttosto che sistemica, del muscolo scheletrico sfruttando la capacit\u00e0 intrinseca di legame con eparina dell&#8217;isoforma follistatina-288. Come determinato dalla risonanza plasmonica di superficie e dai test basati su cellule, FST288-Fc si lega all&#8217;attivina A, all&#8217;attivina B, alla miostatina (fattore di differenziazione della crescita GDF8) e al GDF11 con elevata affinit\u00e0 e neutralizza la loro attivit\u00e0 in vitro. La somministrazione intramuscolare di FST288-Fc nei topi ha indotto una <strong>crescita robusta e dose-dipendente del muscolo bersaglio<\/strong> ma non dei muscoli circostanti o controlaterali, in contrasto con gli effetti sistemici di una proteina di fusione somministrata localmente che incorpora il recettore dell&#8217;attivina di tipo IIB (ActRIIB-Fc). Inoltre, la somministrazione sistemica di FST288-Fc nei topi non ha alterato la massa muscolare o la composizione corporea come determinato dall&#8217;NMR, che contrasta nuovamente con l&#8217;attivit\u00e0 sistemica pronunciata di ActRIIB-Fc quando somministrato per la stessa via. L&#8217;analisi successiva ha rivelato che FST288-Fc nella circolazione subisce una rapida proteolisi, limitando cos\u00ec la sua attivit\u00e0 ai singoli muscoli colpiti dalla somministrazione intramuscolare. Questi risultati indicano che FST288-Fc pu\u00f2 produrre una crescita localizzata del muscolo scheletrico in modo mirato con potenziale ridotto di effetti sistemici indesiderati. Pertanto, FST288-Fc e agenti simili possono essere utili nel trattamento di disturbi con atrofia muscolare focale, asimmetrica o altrimenti eterogenea.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/elisabettalungo.it\/home\/wp-content\/uploads\/2020\/06\/FOLLISTATINA-288.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download the article<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 80%;\">Copyright \u00a9 2019 The Author(s): Roselyne Castonguay, Jennifer Lachey, Samantha Wallner, Jamie Strand, Katia Liharska, Abigail E. Watanabe, Marishka Cannell, Monique V. Davies, Dianne Sako, Megan E. Troy, Lavanya Krishnan, Aaron W. Mulivor, Huiming Li, Sarah Keates, Mark J. Alexander, R. Scott Pearsall, Ravi Kumar<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La follistatina \u00e8 una glicoproteina endogena che promuove la crescita e la riparazione del muscolo scheletrico sequestrando i ligandi inibitori della superfamiglia del TGF-\u03b2 e pu\u00f2 quindi avere un potenziale terapeutico per le malattie neuromuscolari. Nell&#8217;articolo seguente si \u00e8 cercato di determinare l&#8217;idoneit\u00e0 di una proteina di nuova concezione (FST288-Fc) per promuovere la crescita localizzata, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3701,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"categories":[364,359],"tags":[435,436,440,439,438,437],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Follistatina-288-Fc - Elisabetta Lungo - Personal Trainer - Perugia - Bastia Umbra - Foligno<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andrea Tenerini\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\"},\"author\":{\"name\":\"Andrea Tenerini\",\"@id\":\"https:\/\/elisabettalungo.it\/home\/#\/schema\/person\/de68f00504c839ffc4219b44674d0f0a\"},\"headline\":\"Follistatina-288-Fc\",\"datePublished\":\"2020-06-06T12:59:28+00:00\",\"dateModified\":\"2020-06-06T13:30:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\"},\"wordCount\":317,\"publisher\":{\"@id\":\"https:\/\/elisabettalungo.it\/home\/#organization\"},\"keywords\":[\"Follistatina\",\"follistatina-288\",\"FST\",\"GDF-11\",\"GDF-8\",\"Miostatina\"],\"articleSection\":[\"Peptidi \/ doping genetico\",\"Supplementazione\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\",\"url\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\",\"name\":\"Follistatina-288-Fc - Elisabetta Lungo - Personal Trainer - Perugia - Bastia Umbra - Foligno\",\"isPartOf\":{\"@id\":\"https:\/\/elisabettalungo.it\/home\/#website\"},\"datePublished\":\"2020-06-06T12:59:28+00:00\",\"dateModified\":\"2020-06-06T13:30:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/elisabettalungo.it\/home\/follistatin-288-fc-fusion-protein-promotes-localized-growth-of-skeletal-muscle\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/elisabettalungo.it\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Follistatina-288-Fc\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/elisabettalungo.it\/home\/#website\",\"url\":\"https:\/\/elisabettalungo.it\/home\/\",\"name\":\"Elisabetta Lungo - Personal Trainer - Perugia - Bastia Umbra - Foligno\",\"description\":\"workout &amp; 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